The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson’s disease brain in association with the pathologic accumulation of alpha-synuclein

The aberrant accumulation of alpha-synuclein (α-syn) is believed to contribute to the onset and pathogenesis of Parkinson’s disease (PD). The autophagy-lysosome pathway (ALP) is responsible for the high capacity clearance of α-syn. ALP dysfunction is documented in PD and pre-clinical evidence sugges...

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Gepubliceerd in:Neurobiol Dis
Hoofdauteurs: Nelson, Michael P., Boutin, Michel, Tse, Tonia E., Lu, Hailin, Haley, Emily D., Ouyang, Xiaosen, Zhang, Jianhua, Auray-Blais, Christiane, Shacka, John J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747987/
https://ncbi.nlm.nih.gov/pubmed/29196214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.11.006
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