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Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
BACKGROUND: Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. However, macroautophagy initiation has been shown to be...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164227/ https://ncbi.nlm.nih.gov/pubmed/21631942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-37 |
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