Načítá se...
Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
BACKGROUND: Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. However, macroautophagy initiation has been shown to be...
Uloženo v:
| Hlavní autoři: | , , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2011
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164227/ https://ncbi.nlm.nih.gov/pubmed/21631942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-37 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|