Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits

The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition(1-3), but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures(4-7). In Alzheimer's disease (AD) and epilepsy, both of which are acc...

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Bibliografski detalji
Izdano u:Nat Med
Glavni autori: You, Jason C., Muralidharan, Kavitha, Park, Jin W., Petrof, Iraklis, Pyfer, Mark S., Corbett, Brian F., LaFrancois, John J., Zheng, Yi, Zhang, Xiaohong, Mohila, Carrie A., Yoshor, Daniel, Rissman, Robert A., Nestler, Eric J., Scharfman, Helen E., Chin, Jeannie
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747956/
https://ncbi.nlm.nih.gov/pubmed/29035369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4413
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