Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are persistence and whether peripheral T cell-based products can respond to malignant or infected cells that may...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zhen, Anjie, Peterson, Christopher W., Carrillo, Mayra A., Reddy, Sowmya Somashekar, Youn, Cindy S., Lam, Brianna B., Chang, Nelson Y., Martin, Heather A., Rick, Jonathan W., Kim, Jennifer, Neel, Nick C., Rezek, Valerie K., Kamata, Masakazu, Chen, Irvin S. Y., Zack, Jerome A., Kiem, Hans-Peter, Kitchen, Scott G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746250/
https://ncbi.nlm.nih.gov/pubmed/29284044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006753
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