Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are persistence and whether peripheral T cell-based products can respond to malignant or infected cells that may...

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Pubblicato in:PLoS Pathog
Autori principali: Zhen, Anjie, Peterson, Christopher W., Carrillo, Mayra A., Reddy, Sowmya Somashekar, Youn, Cindy S., Lam, Brianna B., Chang, Nelson Y., Martin, Heather A., Rick, Jonathan W., Kim, Jennifer, Neel, Nick C., Rezek, Valerie K., Kamata, Masakazu, Chen, Irvin S. Y., Zack, Jerome A., Kiem, Hans-Peter, Kitchen, Scott G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746250/
https://ncbi.nlm.nih.gov/pubmed/29284044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006753
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