Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer

Yes-associated protein 1 (YAP1) acts as an oncogene through dephosphorylation and nuclear translocation, and nuclear accumulation of YAP1 is associated with poor prognosis in gastric cancer (GC). We previously identified ivermectin, an antiparasitic drug, as a YAP1 inhibitor. Here, we aimed to clari...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nambara, Sho, Masuda, Takaaki, Nishio, Miki, Kuramitsu, Shotaro, Tobo, Taro, Ogawa, Yushi, Hu, Qingjiang, Iguchi, Tomohiro, Kuroda, Yousuke, Ito, Shuhei, Eguchi, Hidetoshi, Sugimachi, Keishi, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko, Suzuki, Akira, Mimori, Koshi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746098/
https://ncbi.nlm.nih.gov/pubmed/29296196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22587
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