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TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC)
Expression of the TUSC2 tumor-suppressor gene in TUSC2-deficient NSCLC cells decreased PD-L1 expression and inhibited mTOR activity. Overexpressing TUSC2 or treatment with rapamycin resulted in similar inhibition of PD-L1 expression. Both TUSC2 and rapamycin decreased p70 and SK6 phosphorylation, su...
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| Izdano u: | Oncotarget |
|---|---|
| Glavni autori: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Impact Journals LLC
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5746095/ https://ncbi.nlm.nih.gov/pubmed/29296193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22581 |
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