TUSC2 immunogene therapy synergizes with anti–PD-1 through enhanced proliferation and infiltration of natural killer cells in syngeneic Kras-mutant mouse lung cancer models

Expression of the multikinase inhibitor encoded by tumor suppressor gene TUSC2 (also known as FUS1) is lost or decreased in non-small cell lung carcinoma (NSCLC). TUSC2 delivered systemically by nanovesicles has mediated tumor regression in clinical trials. Because of the role of TUSC2 in regulating...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Meraz, Ismail M, Majidi, Mourad, Cao, Xiaobo, Lin, Heather, Li, Lerong, wang, Jing, Baladandayuthapani, Veera, Rice, David, Sepesi, Boris, Ji, Lin, Roth, Jack A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909977/
https://ncbi.nlm.nih.gov/pubmed/29339375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0273
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