TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC)

Expression of the TUSC2 tumor-suppressor gene in TUSC2-deficient NSCLC cells decreased PD-L1 expression and inhibited mTOR activity. Overexpressing TUSC2 or treatment with rapamycin resulted in similar inhibition of PD-L1 expression. Both TUSC2 and rapamycin decreased p70 and SK6 phosphorylation, su...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Cao, Xiaobo, Zhao, Yang, Wang, Jing, Dai, Bingbing, Gentile, Emanuela, Lin, Jing, Pu, Xingxiang, Ji, Lin, Wu, Shuhong, Meraz, Ismail, Majidi, Mourad, Roth, Jack A.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746095/
https://ncbi.nlm.nih.gov/pubmed/29296193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22581
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