N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways

BACKGROUND: Activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of Alzheimer’s and Parkinson’s disease. To identify the most effective anti-neuroinflammatory agent, we designed and synthesized a family...

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Veröffentlicht in:BMC Neurosci
Hauptverfasser: Subedi, Lalita, Kwon, Oh Wook, Pak, Chaeho, Lee, Goeun, Lee, Kangwoo, Kim, Hakwon, Kim, Sun Yeou
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745756/
https://ncbi.nlm.nih.gov/pubmed/29281977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-017-0399-3
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