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Impact of FHIT loss on the translation of cancer-associated mRNAs

BACKGROUND: FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss contributes to cancer, and conversely, how FHIT acts to maintain genome integrity and suppress malignancy. Fhit belo...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Kiss, Daniel L., Baez, William, Huebner, Kay, Bundschuh, Ralf, Schoenberg, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745650/
https://ncbi.nlm.nih.gov/pubmed/29282095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0749-x
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