TRPC4 Inactivation Confers a Survival Benefit in Severe Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary arterial pressure with lumen-occluding neointimal and plexiform lesions. Activation of store-operated calcium entry channels promotes contraction and proliferation of lung vascular cells. TRPC4 is a ubiquitously expressed s...

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Опубликовано в: :Am J Pathol
Главные авторы: Alzoubi, Abdallah, Almalouf, Philip, Toba, Michie, O'Neill, Kealan, Qian, Xun, Francis, Michael, Taylor, Mark S., Alexeyev, Mikhail, McMurtry, Ivan F., Oka, Masahiko, Stevens, Troy
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745549/
https://ncbi.nlm.nih.gov/pubmed/24113457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.016
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