A Novel Vascular Homing Peptide Strategy to Selectively Enhance Pulmonary Drug Efficacy in Pulmonary Arterial Hypertension

A major limitation in the pharmacological treatment of pulmonary arterial hypertension (PAH) is the lack of pulmonary vascular selectivity. Recent studies have identified a tissue-penetrating homing peptide, CARSKNKDC (CAR), which specifically homes to hypertensive pulmonary arteries but not to norm...

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Detalhes bibliográficos
Main Authors: Toba, Michie, Alzoubi, Abdallah, O’Neill, Kealan, Abe, Kohtaro, Urakami, Takeo, Komatsu, Masanobu, Alvarez, Diego, Järvinen, Tero A.H., Mann, David, Ruoslahti, Erkki, McMurtry, Ivan F., Oka, Masahiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906494/
https://ncbi.nlm.nih.gov/pubmed/24401613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.10.008
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