Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells

We previously reported that raloxifene, an estrogen receptor modulator, is also a ligand for the aryl hydrocarbon receptor (AhR). Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. We performed structure–activity studies with seven raloxifene analogs to be...

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Detalhes bibliográficos
Publicado no:Biology (Basel)
Main Authors: Jang, Hyo Sang, Pearce, Martin, O’Donnell, Edmond F., Nguyen, Bach Duc, Truong, Lisa, Mueller, Monica J., Bisson, William H., Kerkvliet, Nancy I., Tanguay, Robert L., Kolluri, Siva Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745446/
https://ncbi.nlm.nih.gov/pubmed/29194351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology6040041
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