TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4(+) T Cell Differentiation

FICZ and TCDD, two high-affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic differences in AhR activation, although differences in sensitivity...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Ehrlich, Allison K, Pennington, Jamie M, Bisson, William H, Kolluri, Siva K, Kerkvliet, Nancy I
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Aryl Hydrocarbon Receptor Ligands and T Cell Differentiation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837604/
https://ncbi.nlm.nih.gov/pubmed/29040756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx215
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