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TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4(+) T Cell Differentiation
FICZ and TCDD, two high-affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic differences in AhR activation, although differences in sensitivity...
Gorde:
| Argitaratua izan da: | Toxicol Sci |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5837604/ https://ncbi.nlm.nih.gov/pubmed/29040756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx215 |
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