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On the Structure and Mechanism of Two-Pore Channels
In eukaryotes, two-pore channels (TPC1-3) comprise a family of ion channels that regulate the conductance of Na(+) and Ca(2+) ions across cellular membranes. TPC1-3 form endolysosomal channels, but TPC3 can also function in the plasma membrane. TPC1/3 are voltage-gated channels, but TPC2 opens in re...
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| Udgivet i: | FEBS J |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5745306/ https://ncbi.nlm.nih.gov/pubmed/28656706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14154 |
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