TFPIα interacts with FVa and FXa to inhibit prothrombinase during the initiation of coagulation

Tissue factor pathway inhibitor α (TFPIα) inhibits prothrombinase, the thrombin-generating complex of factor Xa (FXa) and factor Va (FVa), during the initiation of coagulation. This inhibition requires binding of a conserved basic region within TFPIα to a conserved acidic region in FXa-activated and...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Wood, Jeremy P., Petersen, Helle H., Yu, Bingke, Wu, Xiaoai, Hilden, Ida, Mast, Alan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745139/
https://ncbi.nlm.nih.gov/pubmed/29291252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017011098
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