Reduced prothrombinase inhibition by tissue factor pathway inhibitor contributes to the factor V Leiden hypercoagulable state

Activated factor V (FVa) and factor X (FXa) form prothrombinase, which converts prothrombin to thrombin. The α isoform of tissue factor pathway inhibitor (TFPI) dampens early procoagulant events, partly by interacting with FV. FV Leiden (FVL) is the most common genetic thrombophilia in whites. Throm...

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Vydáno v:Blood Adv
Hlavní autoři: Wood, Jeremy P., Baumann Kreuziger, Lisa M., Ellery, Paul E. R., Maroney, Susan A., Mast, Alan E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456269/
https://ncbi.nlm.nih.gov/pubmed/28580443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016002295
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