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Blocking Inhibition of Prothrombinase by Tissue Factor Pathway Inhibitor alpha: A Procoagulant Property of Heparins
Unfractionated heparin (UFH) has procoagulant activity in antithrombin/heparin cofactor II (HCII)-depleted plasma. UFH prevents tissue factor pathway inhibitor alpha (TFPIα) from inhibiting the procoagulant enzyme complex, prothrombinase, providing a possible mechanism for its procoagulant activity....
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| Publicado no: | Br J Haematol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035186/ https://ncbi.nlm.nih.gov/pubmed/27301751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14182 |
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