The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency

Loss-of-function mutations in genes encoding the signaling protein tumor necrosis factor receptor–associated factor 3 (TRAF3) are commonly found in human B-cell malignancies, especially multiple myeloma and B-cell lymphoma (BCL). B-cell TRAF3 deficiency results in enhanced cell survival, elevated ac...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: Bangalore-Prakash, Pradeep, Stunz, Laura L., Mambetsariev, Nurbek, Whillock, Amy L., Hostager, Bruce S., Bishop, Gail A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2017
Assuntos:
Immunobiology and Immunotherapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745131/
https://ncbi.nlm.nih.gov/pubmed/29296923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017009670
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