Assessment of oncolytic HSV efficacy following increased entry-receptor expression in malignant peripheral nerve sheath tumor cell lines

Limited expression and distribution of nectin-1, the major herpes simplex virus (HSV) type-1 entry-receptor, within tumors has been proposed as an impediment to oncolytic HSV (oHSV) therapy. To determine whether resistance to oHSVs in malignant peripheral nerve sheath tumors (MPNSTs) was explained b...

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Veröffentlicht in:Gene Ther
Hauptverfasser: Jackson, JD, McMorris, AM, Roth, JC, Coleman, JM, Whitley, RJ, Gillespie, GY, Carroll, SL, Markert, JM, Cassady, KA
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745010/
https://ncbi.nlm.nih.gov/pubmed/25119379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.72
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