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Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1.

Oncolytic type-1 herpes simplex viruses (oHSVs) lacking the γ134.5 neurovirulence gene are being evaluated for treatment of a variety of malignancies. oHSVs replicate within and directly kill permissive cancer cells. To augment their anti-tumor activity, oHSVs have been engineered to express immunos...

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主要な著者: David C Gaston, Carl I Odom, Li Li, James M Markert, Justin C Roth, Kevin A Cassady, Richard J Whitley, Jacqueline N Parker
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2013-01-01
シリーズ:PLoS ONE
オンライン・アクセス:http://europepmc.org/articles/PMC3842420?pdf=render
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