Production of Bioactive Soluble Interleukin-15 in Complex with Interleukin-15 Receptor Alpha from a Conditionally-Replicating Oncolytic HSV-1

Oncolytic type-1 herpes simplex viruses (oHSVs) lacking the γ(1)34.5 neurovirulence gene are being evaluated for treatment of a variety of malignancies. oHSVs replicate within and directly kill permissive cancer cells. To augment their anti-tumor activity, oHSVs have been engineered to express immun...

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Autors principals: Gaston, David C., Odom, Carl I., Li, Li, Markert, James M., Roth, Justin C., Cassady, Kevin A., Whitley, Richard J., Parker, Jacqueline N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842420/
https://ncbi.nlm.nih.gov/pubmed/24312353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081768
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