Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia

The intercellular adhesion molecule-5 (ICAM-5) regulates neurite outgrowth and synaptic maturation. ICAM-5 overexpression in the hippocampal neurons induces filopodia formation in vitro. Since microglia are known to prune supernumerous synapses during development, we characterized the regulatory eff...

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Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Paetau, Sonja, Rolova, Taisia, Ning, Lin, Gahmberg, Carl G.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743933/
https://ncbi.nlm.nih.gov/pubmed/29311819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00431
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