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ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin

ICAM-5 is a negative regulator of dendritic spine maturation and facilitates the formation of filopodia. Its absence results in improved memory functions, but the mechanisms have remained poorly understood. Activation of NMDA receptors induces ICAM-5 ectodomain cleavage through a matrix metalloprote...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Ning, Lin, Paetau, Sonja, Nyman-Huttunen, Henrietta, Tian, Li, Gahmberg, Carl G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365481/
https://ncbi.nlm.nih.gov/pubmed/25572420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.201410439
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