Lineage specification of human dendritic cell is marked by expression of the transcriptionl factor IRF8 in HSCs and MPPs

The origin and specification of human dendritic cells (DCs) have not been investigated at clonal level. Using clonal assays combined with statistical computation to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34(+) progenitor cells, we show...

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Udgivet i:Nat Immunol
Main Authors: Lee, Jaeyop, Zhou, Yu Jerry, Ma, Wenji, Zhang, Wanwei, Aljoufi, Arafat, Luh, Thomas, Lucero, Kimberly, Liang, Deguang, Thomsen, Matthew, Bhagat, Govind, Shen, Yufeng, Liu, Kang
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743223/
https://ncbi.nlm.nih.gov/pubmed/28650480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3789
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