Organelle-specific single-molecule imaging of α4β2 nicotinic receptors reveals the effect of nicotine on receptor assembly and cell-surface trafficking

Nicotinic acetylcholine receptors (nAChRs) assemble in the endoplasmic reticulum (ER) and traffic to the cell surface as pentamers composed of α and β subunits. Many nAChR subtypes can assemble with varying subunit ratios, giving rise to multiple stoichiometries exhibiting different subcellular loca...

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Vydáno v:J Biol Chem
Hlavní autoři: Fox-Loe, Ashley M., Moonschi, Faruk H., Richards, Christopher I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743088/
https://ncbi.nlm.nih.gov/pubmed/29074617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.801431
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