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The Nicotine Metabolite, Cotinine, Alters the Assembly and Trafficking of a Subset of Nicotinic Acetylcholine Receptors

Exposure to nicotine alters the trafficking and assembly of nicotinic receptors (nAChRs), leading to their up-regulation on the plasma membrane. Although the mechanism is not fully understood, nicotine-induced up-regulation is believed to contribute to nicotine addiction. The effect of cotinine, the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fox, Ashley M., Moonschi, Faruk H., Richards, Christopher I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591823/
https://ncbi.nlm.nih.gov/pubmed/26269589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661827
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