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A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation
β-Amyloid (Aβ) aggregation is thought to initiate a cascade of neurodegenerative events in Alzheimer's disease (AD). Much effort is underway to develop strategies to reduce Aβ concentration or inhibit aggregation. Cathepsin B (CatB) proteolytically degrades Aβ into non-aggregating fragments but...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743080/ https://ncbi.nlm.nih.gov/pubmed/29046353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811448 |
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