Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells

Cell free hemoglobin (Hb), becomes oxidized in the circulation during hemolytic episodes in sickle cell disease (SCD) or thalassemia and may potentially cause major complications that are damaging to the vascular system. Hemolytic anemias are commonly associated with pulmonary hypertension (PH) and...

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Bibliografiska uppgifter
I publikationen:Front Physiol
Huvudupphovsmän: Jana, Sirsendu, Meng, Fantao, Hirsch, Rhoda E., Friedman, Joel M., Alayash, Abdu I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2017
Ämnen:
Physiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742253/
https://ncbi.nlm.nih.gov/pubmed/29311995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.01082
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