Lack of Adrenomedullin Aggravates Acute TNBS-Induced Colitis Symptoms in Mice, Especially in Females

Adrenomedullin (AM) is a biologically active peptide which has been tested as a new therapy for inflammatory bowel disease (IBD) in animal models and in patients with severe ulcerative colitis. We used an inducible knockout (KO) mouse model for AM to evaluate the effects of endogenous levels of this...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Martínez-Herrero, Sonia, Larrayoz, Ignacio M., Narro-Íñiguez, Judit, Rubio-Mediavilla, Susana, Martínez, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742153/
https://ncbi.nlm.nih.gov/pubmed/29311984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.01058
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