Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

Cortisol synthase (CYP11B1) is the main enzyme for the endogenous synthesis of cortisol and its inhibition is a potential way for the treatment of diseases associated with increased cortisol levels, such as Cushing's syndrome, metabolic diseases, and delayed wound healing. Aldosterone synthase...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Chem
Prif Awduron: Akram, Muhammad, Waratchareeyakul, Watcharee, Haupenthal, Joerg, Hartmann, Rolf W., Schuster, Daniela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742115/
https://ncbi.nlm.nih.gov/pubmed/29312923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2017.00104
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