Donepezil suppresses intracellular Ca(2+) mobilization through the PI3K pathway in rodent microglia

BACKGROUND: Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related to the inflammatory responses mediated by mi...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Haraguchi, Yoshinori, Mizoguchi, Yoshito, Ohgidani, Masahiro, Imamura, Yoshiomi, Murakawa-Hirachi, Toru, Nabeta, Hiromi, Tateishi, Hiroshi, Kato, Takahiro A., Monji, Akira
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741946/
https://ncbi.nlm.nih.gov/pubmed/29273047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1033-0
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