Donepezil suppresses intracellular Ca(2+) mobilization through the PI3K pathway in rodent microglia

BACKGROUND: Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related to the inflammatory responses mediated by mi...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Haraguchi, Yoshinori, Mizoguchi, Yoshito, Ohgidani, Masahiro, Imamura, Yoshiomi, Murakawa-Hirachi, Toru, Nabeta, Hiromi, Tateishi, Hiroshi, Kato, Takahiro A., Monji, Akira
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741946/
https://ncbi.nlm.nih.gov/pubmed/29273047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1033-0
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