Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation

The success of tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), relies on the ability to survive in host cells and escape to immune surveillance and activation. We recently demonstrated that Mtb manipulation of host lysosomal cathepsins in macrophages leads to decreased enzymatic activi...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Pires, David, Bernard, Elliott M., Pombo, João Palma, Carmo, Nuno, Fialho, Catarina, Gutierrez, Maximiliano Gabriel, Bettencourt, Paulo, Anes, Elsa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741618/
https://ncbi.nlm.nih.gov/pubmed/29326705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01819
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