Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages

Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and M. microti) but not against M. bovis and M. avium. The latter two are mycobacterial species involved in human and cattle tuberculosis and in HIV coinfections, respectively. PZA is a firs...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pires, David, Valente, Emília, Simões, Marta Filipa, Carmo, Nuno, Testa, Bernard, Constantino, Luís, Anes, Elsa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649235/
https://ncbi.nlm.nih.gov/pubmed/26438493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00936-15
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