Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages

Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and M. microti) but not against M. bovis and M. avium. The latter two are mycobacterial species involved in human and cattle tuberculosis and in HIV coinfections, respectively. PZA is a firs...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Pires, David, Valente, Emília, Simões, Marta Filipa, Carmo, Nuno, Testa, Bernard, Constantino, Luís, Anes, Elsa
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Susceptibility
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649235/
https://ncbi.nlm.nih.gov/pubmed/26438493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00936-15
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