Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages

Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and M. microti) but not against M. bovis and M. avium. The latter two are mycobacterial species involved in human and cattle tuberculosis and in HIV coinfections, respectively. PZA is a firs...

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發表在:Antimicrob Agents Chemother
Main Authors: Pires, David, Valente, Emília, Simões, Marta Filipa, Carmo, Nuno, Testa, Bernard, Constantino, Luís, Anes, Elsa
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
主題:
Susceptibility
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649235/
https://ncbi.nlm.nih.gov/pubmed/26438493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00936-15
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