Structural constraints and enzymatic promiscuity in the Cas6-dependent generation of crRNAs

A hallmark of defense mechanisms based on clustered regularly interspaced short palindromic repeats (CRISPR) and associated sequences (Cas) are the crRNAs that guide these complexes in the destruction of invading DNA or RNA. Three separate CRISPR-Cas systems exist in the cyanobacterium Synechocystis...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Reimann, Viktoria, Alkhnbashi, Omer S., Saunders, Sita J., Scholz, Ingeborg, Hein, Stephanie, Backofen, Rolf, Hess, Wolfgang R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741207/
https://ncbi.nlm.nih.gov/pubmed/27599840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw786
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