Structural constraints and enzymatic promiscuity in the Cas6-dependent generation of crRNAs

A hallmark of defense mechanisms based on clustered regularly interspaced short palindromic repeats (CRISPR) and associated sequences (Cas) are the crRNAs that guide these complexes in the destruction of invading DNA or RNA. Three separate CRISPR-Cas systems exist in the cyanobacterium Synechocystis...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Reimann, Viktoria, Alkhnbashi, Omer S., Saunders, Sita J., Scholz, Ingeborg, Hein, Stephanie, Backofen, Rolf, Hess, Wolfgang R.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741207/
https://ncbi.nlm.nih.gov/pubmed/27599840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw786
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