Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet–Fed Mice

Ββ-Cell adaptation to insulin resistance is necessary to maintain glucose homeostasis in obesity. Failure of this mechanism is a hallmark of type 2 diabetes (T2D). Hence, factors controlling functional β-cell compensation are potentially important targets for the treatment of T2D. Protein kinase D1...

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Udgivet i:Diabetes
Main Authors: Bergeron, Valérie, Ghislain, Julien, Vivot, Kevin, Tamarina, Natalia, Philipson, Louis H., Fielitz, Jens, Poitout, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2018
Fag:
Islet Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741145/
https://ncbi.nlm.nih.gov/pubmed/29038309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0982
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