Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice

Elevated reactive oxygen species (ROS) are linked to insulin resistance and islet dysfunction. Manganese superoxide dismutase (SOD2) is a primary defense against mitochondrial oxidative stress. To test the hypothesis that heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion (GSIS)...

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Bibliographic Details
Main Authors: Kang, Li, Dai, Chunhua, Lustig, Mary E., Bonner, Jeffrey S., Mayes, Wesley H., Mokshagundam, Shilpa, James, Freyja D., Thompson, Courtney S., Lin, Chien-Te, Perry, Christopher G.R., Anderson, Ethan J., Neufer, P. Darrell, Wasserman, David H., Powers, Alvin C.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2014
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207395/
https://ncbi.nlm.nih.gov/pubmed/24947366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1845
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