Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing

Despite being time-consuming and costly, generating genome-edited pigs holds great promise for agricultural, biomedical, and pharmaceutical applications. To further facilitate genome editing in pigs, we report here establishment of a pig line with Cre-inducible Cas9 expression that allows a variety...

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Publicat a:Genome Res
Autors principals: Wang, Kepin, Jin, Qin, Ruan, Degong, Yang, Yi, Liu, Qishuai, Wu, Han, Zhou, Zhiwei, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Zhao, Bentian, Zhang, Quanjun, Peng, Jiangyun, Lai, Chengdan, Fan, Nana, Liang, Yanhui, Lan, Ting, Li, Nan, Wang, Xiaoshan, Wang, Xinlu, Fan, Yong, Doevendans, Pieter A., Sluijter, Joost P.G., Liu, Pentao, Li, Xiaoping, Lai, Liangxue
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2017
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Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741047/
https://ncbi.nlm.nih.gov/pubmed/29146772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222521.117
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