Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks

The RNA-guided DNA endonuclease Cas9 has emerged as a powerful tool for genome engineering. Cas9 creates targeted double-stranded breaks (DSBs) in the genome. Knockin of specific mutations (precision genome editing) requires homology-directed repair (HDR) of the DSB by synthetic donor DNAs containin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Paix, Alexandre, Folkmann, Andrew, Goldman, Daniel H., Kulaga, Heather, Grzelak, Michael J., Rasoloson, Dominique, Paidemarry, Supriya, Green, Rachel, Reed, Randall R., Seydoux, Geraldine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740635/
https://ncbi.nlm.nih.gov/pubmed/29183983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711979114
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