Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans

Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome editing, but is thought to be less efficient than error-prone nonhomologous end joining in most cell types. We have investigated HDR of double-strand breaks induced by CRISPR-associated protein 9 (Cas9) in Ca...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Paix, Alexandre, Wang, Yuemeng, Smith, Harold E., Lee, Chih-Yung S., Calidas, Deepika, Lu, Tu, Smith, Jarrett, Schmidt, Helen, Krause, Michael W., Seydoux, Geraldine
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2014
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256755/
https://ncbi.nlm.nih.gov/pubmed/25249454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.170423
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