A framework for exhaustively mapping functional missense variants

Although we now routinely sequence human genomes, we can confidently identify only a fraction of the sequence variants that have a functional impact. Here, we developed a deep mutational scanning framework that produces exhaustive maps for human missense variants by combining random codon mutagenesi...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Weile, Jochen, Sun, Song, Cote, Atina G, Knapp, Jennifer, Verby, Marta, Mellor, Joseph C, Wu, Yingzhou, Pons, Carles, Wong, Cassandra, van Lieshout, Natascha, Yang, Fan, Tasan, Murat, Tan, Guihong, Yang, Shan, Fowler, Douglas M, Nussbaum, Robert, Bloom, Jesse D, Vidal, Marc, Hill, David E, Aloy, Patrick, Roth, Frederick P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740498/
https://ncbi.nlm.nih.gov/pubmed/29269382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20177908
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