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Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods

BACKGROUND: Thiopurine S-methyltransferase (TPMT) enzyme metabolizes thiopurine drugs which are widely used in various disciplines as well as in leukemias. Individual enzyme activity varies depending on the genetic polymorphisms of TPMT gene located at chromosome 6. Up to 14% of popu-lation is known...

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Detalhes bibliográficos
Publicado no:Cardiovasc Hematol Agents Med Chem
Main Authors: Asadov, Chingiz, Aliyeva, Gunay, Mustafayeva, Kamala
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740490/
https://ncbi.nlm.nih.gov/pubmed/28552060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1871525715666170529091921
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