Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

Reactive oxygen species (ROS) contribute to the development of non-alcoholic fatty liver disease. ROS generation by infiltrating macrophages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX) activation. Here, we show that palmitate-stimulated CD11b(+)F4...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kim, So Yeon, Jeong, Jong-Min, Kim, Soo Jin, Seo, Wonhyo, Kim, Myung-Ho, Choi, Won-Mook, Yoo, Wonbeak, Lee, Jun-Hee, Shim, Young-Ri, Yi, Hyon-Seung, Lee, Young-Sun, Eun, Hyuk Soo, Lee, Byung Seok, Chun, Kwangsik, Kang, Suk-Jo, Kim, Sun Chang, Gao, Bin, Kunos, George, Kim, Ho Min, Jeong, Won-Il
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740170/
https://ncbi.nlm.nih.gov/pubmed/29269727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02325-2
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