Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that normal mammary epithelial cells consume glutamine, but do not secrete glutamate. Indeed, low...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Dornier, Emmanuel, Rabas, Nicolas, Mitchell, Louise, Novo, David, Dhayade, Sandeep, Marco, Sergi, Mackay, Gillian, Sumpton, David, Pallares, Maria, Nixon, Colin, Blyth, Karen, Macpherson, Iain R., Rainero, Elena, Norman, Jim C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740148/
https://ncbi.nlm.nih.gov/pubmed/29269878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02101-2
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