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Cancer cells with trapped nuclei cut their way through the extracellular matrix

When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates trafficking of endosomal vesicles containing the matrix metallo...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Dornier, Emmanuel, Norman, Jim C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160491/
https://ncbi.nlm.nih.gov/pubmed/30262828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06351-6
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