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Cancer cells with trapped nuclei cut their way through the extracellular matrix
When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates trafficking of endosomal vesicles containing the matrix metallo...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6160491/ https://ncbi.nlm.nih.gov/pubmed/30262828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06351-6 |
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